| 1 | SerA | 01/06/2022 | Juventus - Napoli | 1 - 1 | Szczęsny | Mertens | 23' fp | 0 - 1 |
| 2 | SerA | 01/09/2022 | Roma - Juventus | 3 - 4 | Szczęsny | Abraham | 11' fp | 1 - 0 |
| 3 | SerA | 01/09/2022 | Roma - Juventus | 3 - 4 | Szczęsny | Mkhitaryan | 3' sp | 2 - 1 |
| 4 | SerA | 01/09/2022 | Roma - Juventus | 3 - 4 | Szczęsny | Pellegrini | 8' sp | 3 - 1 |
| 5 | SI | 01/12/2022 | Inter - Juventus | 2 - 1 | Perin | Martínez L. penalty | 35' fp | 1 - 1 |
| 6 | SI | 01/12/2022 | Inter - Juventus | 2 - 1 | Perin | Sánchez | 16' set | 2 - 1 |
| 7 | CI | 01/18/2022 | Juventus - Sampdoria | 4 - 1 | Perin | Conti A. | 18' sp | 2 - 1 |
| 8 | CI | 02/10/2022 | Juventus - Sassuolo | 2 - 1 | Perin | Traorè | 24' fp | 1 - 1 |
| 9 | SerA | 02/13/2022 | Atalanta - Juventus | 1 - 1 | Szczęsny | Malinovskyi | 31' sp | 1 - 0 |
| 10 | SerA | 02/18/2022 | Juventus - Torino | 1 - 1 | Szczęsny | Belotti | 17' sp | 1 - 1 |
| 11 | UCL | 02/22/2022 | Villarreal (SPA) - Juventus | 1 - 1 | Szczęsny | Parejo | 21' sp | 1 - 1 |
| 12 | SerA | 02/26/2022 | Empoli - Juventus | 2 - 3 | Szczęsny | Żurkowski | 40' fp | 1 - 1 |
| 13 | SerA | 02/26/2022 | Empoli - Juventus | 2 - 3 | Szczęsny | La Mantia | 31' sp | 2 - 3 |
| 14 | SerA | 03/12/2022 | Sampdoria - Juventus | 1 - 3 | Szczęsny | Sabiri | 39' sp | 1 - 2 |
| 15 | UCL | 03/16/2022 | Juventus - Villarreal (SPA) | 0 - 3 | Szczęsny | Moreno penalty | 33' sp | 0 - 1 |
| 16 | UCL | 03/16/2022 | Juventus - Villarreal (SPA) | 0 - 3 | Szczęsny | Torres | 40' sp | 0 - 2 |
| 17 | UCL | 03/16/2022 | Juventus - Villarreal (SPA) | 0 - 3 | Szczęsny | Danjuma penalty | 47' sp | 0 - 3 |
| 18 | SerA | 04/03/2022 | Juventus - Inter | 0 - 1 | Szczęsny | Çalhanoğlu penalty | 50' fp | 0 - 1 |
| 19 | SerA | 04/09/2022 | Cagliari - Juventus | 1 - 2 | Szczęsny | Zé Pedro | 10' fp | 1 - 0 |
| 20 | SerA | 04/16/2022 | Juventus - Bologna | 1 - 1 | Szczęsny | Arnautović | 7' sp | 0 - 1 |
| 21 | SerA | 04/25/2022 | Sassuolo - Juventus | 1 - 2 | Szczęsny | Raspadori | 39' fp | 1 - 0 |
| 22 | SerA | 05/01/2022 | Juventus - Venezia | 2 - 1 | Szczęsny | Aramu | 26' sp | 1 - 1 |
| 23 | SerA | 05/06/2022 | Genoa - Juventus | 2 - 1 | Szczęsny | Guðmundsson | 42' sp | 1 - 1 |
| 24 | SerA | 05/06/2022 | Genoa - Juventus | 2 - 1 | Szczęsny | Criscito penalty | 51' sp | 2 - 1 |
| 25 | CI | 05/11/2022 | Juventus - Inter | 2 - 4 | Perin | Barella | 7' fp | 0 - 1 |
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