| 1 | CI | 08/20/1980 | Udinese - Juventus | 2 - 2 | Zoff | Tesser | 7' sp | 1 - 0 |
| 2 | CI | 08/20/1980 | Udinese - Juventus | 2 - 2 | Zoff | Pradella | 14' sp | 2 - 0 |
| 3 | CI | 09/07/1980 | Juventus - Genoa | 3 - 1 | Zoff | Russo | 20' sp | 2 - 1 |
| 4 | SerA | 09/14/1980 | Cagliari - Juventus | 1 - 1 | Zoff | Selvaggi | 19' fp | 1 - 0 |
| 5 | SerA | 09/28/1980 | Brescia - Juventus | 1 - 1 | Zoff | Penzo | 11' fp | 1 - 0 |
| 6 | CU | 10/01/1980 | Panathinaikos Athens (GRE) - Juventus | 4 - 2 | Zoff | Gentile C. own goal | 31' fp | 1 - 0 |
| 7 | CU | 10/01/1980 | Panathinaikos Athens (GRE) - Juventus | 4 - 2 | Zoff | Andreuchi | 36' fp | 2 - 0 |
| 8 | CU | 10/01/1980 | Panathinaikos Athens (GRE) - Juventus | 4 - 2 | Zoff | Livathinos | 24' sp | 3 - 1 |
| 9 | CU | 10/01/1980 | Panathinaikos Athens (GRE) - Juventus | 4 - 2 | Zoff | Delikaris | 42' sp | 4 - 2 |
| 10 | SerA | 10/05/1980 | Juventus - Bologna | 0 - 1 | Zoff | Paris penalty | 38' sp | 0 - 1 |
| 11 | CU | 10/22/1980 | Widzew Łódź (POL) - Juventus | 3 - 1 | Zoff | Grębosz | 30' fp | 1 - 0 |
| 12 | CU | 10/22/1980 | Widzew Łódź (POL) - Juventus | 3 - 1 | Zoff | Pięta | 24' sp | 2 - 1 |
| 13 | CU | 10/22/1980 | Widzew Łódź (POL) - Juventus | 3 - 1 | Zoff | Smolarek | 33' sp | 3 - 1 |
| 14 | SerA | 10/26/1980 | Juventus - Torino | 1 - 2 | Zoff | Graziani F. | 15' sp | 1 - 1 |
| 15 | SerA | 10/26/1980 | Juventus - Torino | 1 - 2 | Zoff | Graziani F. | 31' sp | 1 - 2 |
| 16 | CU | 11/05/1980 | Juventus - Widzew Łódź (POL) | 3 - 1 | Zoff | Pięta | 13' sp | 2 - 1 |
| 17 | SerA | 11/23/1980 | Juventus - Inter | 2 - 1 | Zoff | Ambu | 34' sp | 2 - 1 |
| 18 | SerA | 12/14/1980 | Juventus - Pistoiese | 4 - 1 | Zoff | Chimenti | 5' sp | 3 - 1 |
| 19 | SerA | 12/28/1980 | Avellino - Juventus | 1 - 1 | Zoff | Piga | 40' sp | 1 - 1 |
| 20 | SerA | 01/25/1981 | Juventus - Napoli | 1 - 1 | Zoff | Pellegrini C. | 2' fp | 0 - 1 |
| 21 | SerA | 02/08/1981 | Juventus - Cagliari | 1 - 1 | Zoff | Virdis | 42' fp | 0 - 1 |
| 22 | SerA | 02/15/1981 | Como - Juventus | 1 - 2 | Zoff | Nicoletti penalty | 24' sp | 1 - 2 |
| 23 | SerA | 03/01/1981 | Bologna - Juventus | 1 - 5 | Zoff | Fiorini penalty | 43' sp | 1 - 5 |
| 24 | CI | 03/04/1981 | Avellino - Juventus | 1 - 3 | Zoff | Zoff own goal | 28' fp | 1 - 0 |
| 25 | SerA | 03/22/1981 | Juventus - Perugia | 2 - 1 | Zoff | De Rosa | 36' sp | 0 - 1 |
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