| 1 | SerA | 28/08/2021 | Juventus - Empoli | 0 - 1 | Szczęsny | Mancuso | 21' pt | 0 - 1 |
| 2 | SerA | 19/09/2021 | Juventus - Milan | 1 - 1 | Szczęsny | Rebić | 31' st | 1 - 1 |
| 3 | SerA | 26/09/2021 | Juventus - Sampdoria | 3 - 2 | Perin | Yoshida | 44' pt | 2 - 1 |
| 4 | SerA | 26/09/2021 | Juventus - Sampdoria | 3 - 2 | Perin | Candreva | 38' st | 3 - 2 |
| 5 | SerA | 27/10/2021 | Juventus - Sassuolo | 1 - 2 | Perin | Frattesi | 44' pt | 0 - 1 |
| 6 | SerA | 27/10/2021 | Juventus - Sassuolo | 1 - 2 | Perin | Lopez | 50' st | 1 - 2 |
| 7 | UCL | 02/11/2021 | Juventus - Zenit FC (RUS) | 4 - 2 | Szczęsny | Bonucci autorete | 26' pt | 1 - 1 |
| 8 | UCL | 02/11/2021 | Juventus - Zenit FC (RUS) | 4 - 2 | Szczęsny | Azmoun | 47' st | 4 - 2 |
| 9 | SerA | 27/11/2021 | Juventus - Atalanta | 0 - 1 | Szczęsny | Zapata D. | 28' pt | 0 - 1 |
| 10 | SerA | 06/01/2022 | Juventus - Napoli | 1 - 1 | Szczęsny | Mertens | 23' pt | 0 - 1 |
| 11 | CI | 18/01/2022 | Juventus - Sampdoria | 4 - 1 | Perin | Conti A. | 18' st | 2 - 1 |
| 12 | CI | 10/02/2022 | Juventus - Sassuolo | 2 - 1 | Perin | Traorè | 24' pt | 1 - 1 |
| 13 | SerA | 18/02/2022 | Juventus - Torino | 1 - 1 | Szczęsny | Belotti | 17' st | 1 - 1 |
| 14 | UCL | 16/03/2022 | Juventus - Villarreal (SPA) | 0 - 3 | Szczęsny | Moreno rigore | 33' st | 0 - 1 |
| 15 | UCL | 16/03/2022 | Juventus - Villarreal (SPA) | 0 - 3 | Szczęsny | Torres | 40' st | 0 - 2 |
| 16 | UCL | 16/03/2022 | Juventus - Villarreal (SPA) | 0 - 3 | Szczęsny | Danjuma rigore | 47' st | 0 - 3 |
| 17 | SerA | 03/04/2022 | Juventus - Inter | 0 - 1 | Szczęsny | Çalhanoğlu rigore | 50' pt | 0 - 1 |
| 18 | SerA | 16/04/2022 | Juventus - Bologna | 1 - 1 | Szczęsny | Arnautović | 7' st | 0 - 1 |
| 19 | SerA | 01/05/2022 | Juventus - Venezia | 2 - 1 | Szczęsny | Aramu | 26' st | 1 - 1 |
| 20 | SerA | 16/05/2022 | Juventus - Lazio | 2 - 2 | Perin | Alex Sandro autorete | 6' st | 2 - 1 |
| 21 | SerA | 16/05/2022 | Juventus - Lazio | 2 - 2 | Perin | Milinković-Savić S. | 51' st | 2 - 2 |
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