| 1 | CI | 20/08/1980 | Udinese - Juventus | 2 - 2 | Zoff | Tesser | 7' st | 1 - 0 |
| 2 | CI | 20/08/1980 | Udinese - Juventus | 2 - 2 | Zoff | Pradella | 14' st | 2 - 0 |
| 3 | CI | 07/09/1980 | Juventus - Genoa | 3 - 1 | Zoff | Russo | 20' st | 2 - 1 |
| 4 | SerA | 14/09/1980 | Cagliari - Juventus | 1 - 1 | Zoff | Selvaggi | 19' pt | 1 - 0 |
| 5 | SerA | 28/09/1980 | Brescia - Juventus | 1 - 1 | Zoff | Penzo | 11' pt | 1 - 0 |
| 6 | CU | 01/10/1980 | Panathinaikos Atene (GRE) - Juventus | 4 - 2 | Zoff | Gentile C. autorete | 31' pt | 1 - 0 |
| 7 | CU | 01/10/1980 | Panathinaikos Atene (GRE) - Juventus | 4 - 2 | Zoff | Andreuchi | 36' pt | 2 - 0 |
| 8 | CU | 01/10/1980 | Panathinaikos Atene (GRE) - Juventus | 4 - 2 | Zoff | Livathinos | 24' st | 3 - 1 |
| 9 | CU | 01/10/1980 | Panathinaikos Atene (GRE) - Juventus | 4 - 2 | Zoff | Delikaris | 42' st | 4 - 2 |
| 10 | SerA | 05/10/1980 | Juventus - Bologna | 0 - 1 | Zoff | Paris rigore | 38' st | 0 - 1 |
| 11 | CU | 22/10/1980 | Widzew Lodz (POL) - Juventus | 3 - 1 | Zoff | Grębosz | 30' pt | 1 - 0 |
| 12 | CU | 22/10/1980 | Widzew Lodz (POL) - Juventus | 3 - 1 | Zoff | Pięta | 24' st | 2 - 1 |
| 13 | CU | 22/10/1980 | Widzew Lodz (POL) - Juventus | 3 - 1 | Zoff | Smolarek | 33' st | 3 - 1 |
| 14 | SerA | 26/10/1980 | Juventus - Torino | 1 - 2 | Zoff | Graziani F. | 15' st | 1 - 1 |
| 15 | SerA | 26/10/1980 | Juventus - Torino | 1 - 2 | Zoff | Graziani F. | 31' st | 1 - 2 |
| 16 | CU | 05/11/1980 | Juventus - Widzew Lodz (POL) | 3 - 1 | Zoff | Pięta | 13' st | 2 - 1 |
| 17 | SerA | 23/11/1980 | Juventus - Inter | 2 - 1 | Zoff | Ambu | 34' st | 2 - 1 |
| 18 | SerA | 14/12/1980 | Juventus - Pistoiese | 4 - 1 | Zoff | Chimenti | 5' st | 3 - 1 |
| 19 | SerA | 28/12/1980 | Avellino - Juventus | 1 - 1 | Zoff | Piga | 40' st | 1 - 1 |
| 20 | SerA | 25/01/1981 | Juventus - Napoli | 1 - 1 | Zoff | Pellegrini C. | 2' pt | 0 - 1 |
| 21 | SerA | 08/02/1981 | Juventus - Cagliari | 1 - 1 | Zoff | Virdis | 42' pt | 0 - 1 |
| 22 | SerA | 15/02/1981 | Como - Juventus | 1 - 2 | Zoff | Nicoletti rigore | 24' st | 1 - 2 |
| 23 | SerA | 01/03/1981 | Bologna - Juventus | 1 - 5 | Zoff | Fiorini rigore | 43' st | 1 - 5 |
| 24 | CI | 04/03/1981 | Avellino - Juventus | 1 - 3 | Zoff | Zoff autorete | 28' pt | 1 - 0 |
| 25 | SerA | 22/03/1981 | Juventus - Perugia | 2 - 1 | Zoff | De Rosa | 36' st | 0 - 1 |
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